Peritoneal dialysis and peritoneal fibrosis: molecular mechanisms, risk factors and prospects for prevention

Peritoneal dialysis (PD) leads to structural and functional changes in the peritoneal membrane, endpoint of which is fibrosis. fibrosis diagnosed 50% 80% PD patients within 1 2 years treatment initiation, respectively. A key role development played by mesothelial-mesenchymal transformation, a complex biological process transition from mesothelium mesenchyme. This review summarizes current knowledge on function morphology, molecular mechanisms development, its clinical consequences during PD. Special attention given established potential risk factors for fibrosis, existing prevention strategies are considered.